Issue 18, 2022
From the journal:

Organic & Biomolecular Chemistry

Cephaloliverols A and B, two sterol-hybrid meroterpenoids from Cephalotaxus oliveri†

Chunyu Jiang,ab   Xiaojie Fan,ab   Deli Zou,ab   Zhanlin Li, ORCID logo ab   Tong Han,c   Bin Lin,d   Huiming Hua ORCID logo *ab  and  Dahong Li ORCID logo *ab  

* Corresponding authors

a Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, China
E-mail: lidahong0203@163.com, huimhua@163.com

b School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China

c Department of Pharmaceutical Engineering, College of Life Science & Technology, Heilongjiang Bayi Agricultural University, 5 Xinfeng Road, Daqing 163319, People's Republic of China

d School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China

Abstract

Cephaloliverols A (1) and B (2), two meroterpenoids based on a sterol and an abietane diterpene possessing a dioxane ring, were isolated from the twigs and leaves of Cephalotaxus oliveri. Their structures were established by spectroscopic analysis and quantum chemical calculation. 1 and 2 represent the first sterol-hybrid meroditerpenoids. The two compounds and their precursors decreased NO production in a dose-dependent manner in LPS-stimulated RAW 264.7 macrophages.

Graphical abstract: Cephaloliverols A and B, two sterol-hybrid meroterpenoids from Cephalotaxus oliveri

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Article information

DOI
https://doi.org/10.1039/D2OB00370H
Article type
Communication
Submitted
22 Feb 2022
Accepted
12 Apr 2022
First published
13 Apr 2022

Org. Biomol. Chem., 2022,20, 3712-3716

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Cephaloliverols A and B, two sterol-hybrid meroterpenoids from Cephalotaxus oliveri

C. Jiang, X. Fan, D. Zou, Z. Li, T. Han, B. Lin, H. Hua and D. Li, Org. Biomol. Chem., 2022, 20, 3712 DOI: 10.1039/D2OB00370H

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